منابع مشابه
Neuromuscular Disorders
Disorders of the neuromuscular unit can result in clinical presentations that range from subtle symptoms to acute respiratory failure with significant morbidity and mortality. In most cases, the pathophysiologic mechanism of these disorders is well understood and permits an organization and understanding based on the level of the nervous system affected. This facilitates an approach that interp...
متن کامل[Neuromuscular disorders]
OBJECTIVE: To discuss the most important aspects for the performance of a differential diagnosis among the main neuromuscular disorders in children, which include diseases affecting the motor unity, i.e. spinal motor neurons, peripheral nerves, neuromuscular junction and muscular fibers. SOURCES: The review of the clinical aspects that should be considered for a prompt differential diagnosis am...
متن کاملRNA-mediated neuromuscular disorders.
Myotonic dystrophy type 1 (DM1) is caused by a CTG expansion mutation located in the 3' untranslated portion of the dystrophica myotonin protein kinase gene. The identification and characterization of RNA-binding proteins that interact with expanded CUG repeats and the discovery that a similar transcribed but untranslated CCTG expansion in an intron causes myotonic dystrophy type 2 (DM2) have u...
متن کاملAutoimmune Neuromuscular Disorders
Autoimmune neuromuscular disorders affecting peripheral nerves, neuromuscular junction or muscle have a wide clinical spectrum with diverse pathogenetic mechanisms. Peripheral nervous system may be targeted in the context of complex immune reactions involving different cytokines, antigen-presenting cells, B cells and different types of T cells. Various immunomodulating and cytotoxic treatments ...
متن کاملFeline neuromuscular disorders.
Feline neuromuscular diseases may be classifi ed according to their location as those involving peripheral nerves and/or nerve roots, those involving the neuromuscular junction, and those that involve muscle (1). Each of these neuromuscular diseases will produce lower motor neuron (LMN) disease, however signifi cant variations in clinical signs may occur. Peripheral nerve and muscle diseases re...
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ژورنال
عنوان ژورنال: Current Opinion in Pediatrics
سال: 2013
ISSN: 1040-8703
DOI: 10.1097/mop.0b013e328365de49